Vaccines against hepatitis A are generally well tolerated. There may be pain, redness, tenderness, warmth, and irritation at the site where you receive the injection. Fever, abdominal pain, headache, fatigue, and allergic reactions may also occur.

Serious reactions are rare, but may occur. You should discuss potential side effects with your doctor.

As with all treatments, vaccination with either a hepatitis A vaccine or immune globulin (IG) may not protect 100% of all those who are vaccinated.